Evaluating the neural substrates of effort-expenditure for reward in adults with major depressive disorder and obesity

Hartej Gill,Roger S. McIntyre,Colin Hawco,Nelson B. Rodrigues,Barjot Gill, Joshua D. DiVincenzo, Jonathan M. Lieberman,CéAnn A. Marks,Danielle S. Cha,Orly Lipsitz,Hana Nazal, Ashitija Jasrai,Joshua D. Rosenblat,Rodrigo B. Mansur

Psychiatry Research: Neuroimaging（2023）

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摘要

•MDD and obesity are comorbid conditions that are subserved by deficits in reward functioning.•Functional magnetic resonance imaging was performed in regions associated with reward behaviour.•We observed decreased activation in the left caudate in patients with increased BMI.•MDD and obesity comorbidity may exhibit deficits in cost-benefit decision making.

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关键词

Neuroimaging,Anhedonia,Reward motivation,Reward anticipation,Effort-expenditure,Functional magnetic resonance imaging,Major depressive disorder,Obesity

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