Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition.

Janneke G C Peeters,Arjan Boltjes,Rianne C Scholman,Stephin J Vervoort,Paul J Coffer,Michal Mokry,Sebastiaan J Vastert,Femke van Wijk,Jorg van Loosdregt

Rheumatology (Oxford, England)（2023）

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摘要

This study provides novel insights into epigenetic regulation of inflammatory arthritis patient-derived monocytes and highlights the therapeutic potential of epigenetic modulation for the treatment of inflammatory rheumatic diseases.

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关键词

Autoimmunity,Juvenile Idiopathic Arthritis,Synovium,epigenetics,monocytes

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