The Role of Plasma Cell-Free Mitochondrial DNA and Nuclear DNA in Systemic Lupus Erythematosus.

Hui-Ting Lee,Chen-Sung Lin,Siao-Cian Pan,Wei-Sheng Chen,Chang-Youh Tsai,Yau-Huei Wei

Frontiers in bioscience (Landmark edition)（2022）

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摘要

Higher nDNApcf, lower mtDNApcf, increased ROS-elicited oxidative DNA damage and dysregulated leukocyte CLEC5A expression might be implicated in the pathogenesis of SLE.

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关键词

8-hydroxy-2'-deoxyguanosine (8-OHdG),C-type lectin domain family 5 member A (CLEC5A),malondialdehyde (MDA),plasma cell-free mitochondrial DNA (mtDNA),plasma cell-free nuclear DNA (nDNA),systemic lupus erythematosus (SLE)

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