Insulin regimens during type 1 diabetes pregnancy.

The safety of insulin and all diabetes treatments in early pregnancy, particularly during the first 40 days after conception, is paramount.1,2 However, few insulin (or diabetes device) manufacturers rigorously evaluate newer diabetes treatments before and during pregnancy. In The Lancet Diabetes & Endocrinology Elisabeth R Mathiesen and colleagues3 performed a non-inferiority trial to compare the efficacy and safety of insulin degludec with insulin detemir in combination with insulin aspart, in pregnant women with type 1 diabetes.