Titanium-Platelet Rich Fibrin

Platelet Rich Fibrin (PRF) is the second generation platelet concentrate, developed first by Choukroun, et al. in PRF is a three-dimensional fibrin network that promotes accelerated wound healing, immunity and effective neovascularization, and it supports the three crucial steps of wound healing: 'angiogenesis,' 'immunity' and 'epithelial proliferation'. In addition, PRF, an autogenous fibrin matrix formed only of concentrated blood, provides successful clinical outcomes for the treatment of soft-tissue defects and comparable keratinized tissue gain and tissue thickness when combined with connective tissue grafts. A newer platelet concentrate i.e. Titanium Activated PRF (T-PRF) is a 3rd generation platelet concentrate that helps in regeneration of tissue. Titanium-Prepared, Platelet-Rich Fibrin (T-PRF) was recently developed by Tunali, et al. that avoids any negative effects caused by dry glass or glass-coated plastic tubes. T-PRF plays an important role in increasing soft tissue thickness. T-PRF is promising, especially in soft and hard tissue augmentation, due to its fibrin structure, which is tighter than that of L-PRF, and it is prepared in Grade IV titanium tubes. It produces faster epithelization, less postoperative bleeding, and better wound healing than spontaneous healing. T-PRF also has osteoinductive properties similar to those of bone and preserves tissue volume. Histologically, with the hematoxylin and eosin staining, the fibrin matrix appeared homogeneous in light pink. T-PRF samples showed a highly organized network with continuous integrity compared to the PRF samples. Various treatment modalities such as Leucocyte Platelet Rich Fibrin (L-PRF), bone grafts and membranes, Wound healing, Periodontal regeneration, Guided bone regeneration, Sinus lifting, Peri-implant soft tissue. Titanium Prepared-Platelet Rich Fibrin (T-PRF) has gained attention due to its biocompatibility, thin fibrin meshwork and its long resorption time. This review article gives a brief idea about effectiveness of T-PRF in various dental treatments.