Synthesis, characterization and antibacterial evaluation of N-(2-Morpholinoethyl)-3-phenylquinoxalin-2-amine derivatives

A series of substituted N-(2-Morpholinoethyl)-3-phenylquinoxalin-2-amines (5a-j) (5ab, 5ac) were synthesized in good yield and characterized for their structural confirmation. The pure quinoxaline products were screened for their in-vitro antibacterial activity against Salmonella paratyphi, a well-known food borne pathogen. The preliminary results revealed that among the series, compounds 5a, 5c, 5d, 5e, 5f, 5h, 5ab and 5ac bearing bromo, fluoro, methoxy, methyl groups at para position on phenyl ring which inturn substituted at third position of quinoxaline and methyl, benzoyl groups at sixth position on the quinoxaline were emerged as potential candidates by displaying antisalmonella activity. Among the potential candidates, compounds 5c, 5e, 5f and 5ac were effective against Salmonella whereas compounds 5a, 5f and 5ac effectively inhibited the biofilm formation of Salmonella.