Lewis Acid Promoted Stereoselective Synthesis of Polysubstituted 1,3-Dienes via a Dual 1,3-Sulfur Rearrangement

1,3-Dienes are prevalent substructures in biologically active molecules and versatile building blocks in synthetic chemistry. Herein, using Lewis acids promoted dual 1,3-sulfur rearrangements, we developed an approach for the direct synthesis of 1,3-dithianyl substituted dienes. This method enabled the synthesis of tri- and tetra-substituted 1,3-dienes with high stereoselectivity and good yield under mild reaction conditions.