The Relationship Between Laboratory Findings and Bone Mineral Density in Patients with Osteoporosis

Objective: This study was conducted to investigate the relationship between platelet count, mean platelet volume (MPV), platelet distribution width (PDW), C-reactive protein (CRP), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and osteoporosis (OP) in postmenopausal women. Materials and Methods: Four hundred eighty two patients who had been in menopause for at least 2 years were included in our study. Hemogram, CRP, thyroid-stimulating hormone (TSH), parathyroid hormone, 25-hydroxyvitamin D3 vitamin and dual-energy X-ray absorptiometry results of all patients were recorded. Two hundred ninety five patients with L2-L4 and/or femoral neck T-scores <=-2.5 were determined as the OP group, and 192 patients with L2-L4 and/or Femoral neck T-scores >=-1.0 were determined as the control group. NLR, PLR and SII were calculated and recorded from the hemogram results. Results: The mean age of the OP group was 64.2 +/- 8.3 years, and the mean age of the control group was 56.6 +/- 8.7. Age and vitamin D3 levels were higher in the OP group than in the control group (p<0.001). Leukocytes, neutrophil and MPV levels were found to be lower in the OP group than in the control group (p<0.005). While the L2-L4 T-score was negatively correlated with age and vitamin D3; leukocytes, MPV, PDW, TSH and CRP were positively correlated. The femoral neck T-score was negatively correlated with age and vitamin D3, whereas it was positively correlated with MPV, PDW, TSH and CRP. Conclusion: Platelet functions and immune system markers are effective in bone mineralization in postmenopausal OP patients.