Simultaneous Liver- Kidney Transplantation and The Use of Intraoperative Dialysis- A Monocenter Study (vol 54, pg 1002, 2022)

Background. Simultaneous liver and kidney transplants (SLKT) represent 1.1% of all liver transplants in Poland. Patients undergoing SLKT experience a longer operation time and concurrent kidney dysfunction may aggravate metabolic derangement associated with the procedure. The benefits of intraoperative dialysis (ioHD) in these patients have not been determined. Methods. A retrospective observational study of all adult patients undergoing SLKT in our center from January 2009 till December 2016. Results. Study group consisted of 10 patients with End-Stage Kidney Disease (0.9% of all liver transplants): 6 patients treated with ioHD during SLKT (group 1) and 4 patients managed conservatively (group 2). All recipients were on chronic dialysis. The mean calculated Model for End-Stage Liver Disease score was 21 & PLUSMN; 0.9 in group 1 and 30 & PLUSMN; 9.5 in group 2 (P = .009). The mean preoperative serum potassium was 4.7 & PLUSMN; 0,6 mmol/L in group 1 and 3.97 & PLUSMN; 1,02 in group 2. Intraoperative serum potassium levels were comparable between the groups, but the maximum lactate and minimum bicarbonate levels were significantly worse in group 2. Postreperfusion syndrome occurred in no patient. Dialysis circuit clotting occurred in 50% of ioHD. Six patients (2 in group 1) required renal replacement therapy after SLKT; no patient was on dialysis on discharge. Three patients died within 1 year after surgery (2 in group 2). Conclusions. No patient developed intraoperative hyperkalemia or postreperfusion syndrome. We observed a high frequency of circuit system clotting during ioHD. Clinical benefits of intraoperative hemodialysis during SLKT need to be determined in a larger study.