Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution

Ida Monrad, Signe Risgaard Sahlertz,Stine Sofie Frank Nielsen, Louise Ornskov Pedersen,Mikkel Steen Petersen,Carl Mathias Kobel,Irene Harder Tarpgaard,Merete Storgaard,Klaus Leth Mortensen,Mariane H. Schleimann,Martin Tolstrup,Line K. Vibholm

OPEN FORUM INFECTIOUS DISEASES（2021）

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摘要

We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.

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关键词

CLL, persistent infection, SARS-CoV-2, viral evolution

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