Chromene-based Schiff base ligand: DNA interaction studies and characterization of tetranuclear zinc, nickel and iron complexes

Andrew J. Ressler, Olivia N. Brandt,Ashton Weaver,Jenna E. Poor,Anna Ream, Nicolas A. Summers,Colin D. McMillen,Navindra P. Seeram,William G. Dougherty,Geneive E. Henry

Inorganica Chimica Acta（2023）

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摘要

•A new chromene-aminophenol Schiff base ligand was synthesized.•Tetranuclear Zn, Ni and Fe complexes of the Schiff base ligand were synthesized and characterized.•The chromene-aminophenol ligand cleaves plasmid DNA in the presence of Cu(II) ions.•DNA binding and DNA molecular docking studies indicate that the chromene-aminophenol ligand is a minor groove binder.

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关键词

Chromene-based schiff base,Tetranuclear zinc,Nickel and iron complexes,DNA cleavage,CT-DNA binding,Molecular docking

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