Nickel-mediated Ortho C(sp(2))-H Alkoxylation of Amides
CHEMISTRYSELECT(2022)
Abstract
In this paper, we described nickel-mediated C(sp(2))-H alkoxylation of amide directed by the bidentate auxiliary directing group. The method was proved efficiently to achieve alkoxide derivatives by available alcohol as substrate. We verified the protocol exhibited good yields, which showed great functional group compatibility and broad-range substrate.
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Key words
C-H activation, nickel, simple alcohol, amide-tethered oxazoline (OXa), alkoxylation
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