The interplay of sleep disordered breathing, nocturnal hypoxemia, and endothelial dysfunction in sickle cell disease

•OSA and nocturnal hypoxemia are common in sickle cell disease (SCD).•Intermittent hypoxemia impacts the biology of the endothelium.•Endothelial dysfunction contributes to acute and chronic complications of SCD.•Treatment for sleep disordered breathing can help prevent complications of SCD.