Synthesis of N-acylbenzotriazole using acid anhydride

A novel approach has been adopted for the conversion of carboxylic acids into corresponding N-acyl benzotriazoles utilizing acid anhydride. Our trial has ascertained 2,2,2-trifluoroacetic anhydride in anhydrous dichloromethane as the best candidate to achieve the targeted goal. The reliable and reproducible outcomes of the developed method are easy handling, wide substrate scope, and one-pot high-yielding under mild reaction condition. Moreover, the elimination of external base usage makes this procedure of utmost advantage in N-acyl benzotriazole synthesis. [GRAPHICS] .