Effect of Acyl Chain Length on Hydrophobized Cashew Gum Self-Assembling Nanoparticles: Colloidal Properties and Amphotericin B Delivery

Ana R. Richter, Jose G. Veras-Neto,Jeanlex S. Sousa, Josilayne F. S. Mendes,Raquel O. S. Fontenelle, Stephanie A. N. M. Silva, Jose D. B. Marinho-Filho,Ana J. Araujo,Judith P. A. Feitosa,Haroldo C. B. Paula,Francisco M. Goycoolea,Regina C. M. de Paula

Colloids and Interfaces（2022）

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摘要

Given its many potential applications, cashew gum hydrophobic derivatives have gained increasing attraction in recent years. We report here the effect of acyl chain length on hydrophobized cashew gum derivatives, using acetic, propionic, and butyric anhydrides on self-assembly nanoparticle properties and amphotericin B delivery. Nanoparticles with unimodal particle size distribution, highly negative zeta potential, and low PDI were produced. Butyrate cashew gum nanoparticles presented smaller size (更多

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acylated derivatives,nanoparticles,amphotericin B,colloidal stability

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