Neuropathic Pain in Postmenopausal Osteoporosis Patients Effect on Sleep Quality, Quality of Life and Depression

Objective: In this study, our aimed was to investigate the frequency of neuropathic pain in women diagnosed with postmenopausal osteoporosis (OP), its effects on sleep quality, quality of life, depression and the relationship between these findings. Materials and Methods: Two hundred and fifty women with postmenopausal OP aged 40-75 years were included in our study. The sociodemographic characteristics and risk factors of the participants were questioned and recorded. Additionally, European Osteoporosis Society Quality of Life Questionnaire (QUALEFFO-41) was used to assess the quality of life of all participants, Beck Depression scale (BDS) to determine the presence and level of depression, and the Pittsburgh Sleep Quality index to assess sleep quality. The severity of neuropathic pain was assessed using the Self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) pain scale. Results: The mean age of the patients was 58.57 +/- 7.3 years. According to the S-LANNS scale, 44.8% of the patients were accompanied by neuropathic pain. The mean scores of L1-L4 T (p=0.030) and L1-L4 bone mineral density (p=0.008) were found to be statistically significantly lower in patients with neuropathic pain compared to patients without neuropathic pain. It was found that QUALEFFO-41 total score and subscale scores, BDS score averages, PUKI and subscale scores of the patients with neuropathic pain were statistically significantly higher than those without neuropathic pain. Conclusion: Although OP pain is generally known nociceptive in character, a significant number of patients are accompanied by a neuropathic pain component. The neuropathic pain component is associated with impaired sleep, quality of life and depression in patients with OP.