Can prevent type 1 diabetes?
Revista de la Sociedad Argentina de Diabetes(2022)
Abstract
Type 1 diabetes (T1D) is caused by the autoimmune destruction of β cells of the pancreas, driven by CD4+ and CD8+ T lymphocytes. The humoral branch represented by B lymphocytes is responsible for producing autoantibodies (AAs) against specific antigens such as glutamate decarboxylase (GADA), cellular membrane phosphatase (IA2A/ICA512A), zincT8 transporter (ZincT8A), and the insulin molecule (IAA), all markers of the autoimmune process. These AAs can be detected before the clinical onset of T1D, at the prediabetes type 1 stage (1). The overall risk of progression to T1D is regarded as the presence of 2 or more AAs but differs across patients, being higher with a greater number of AAs (2).
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Key words
diabetes mellitus tipo 1
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