HCV genetic heterogeneity and its host genetics

Hepatitis C represents a major worldwide public health problem. Studies have shown that both genetic diversity of hepatitis C virus (HCV) and genetic polymorphisms of IL-28B, ITPA, and IP-10 in the host are implicated in the progression of hepatitis C, treatment response, and adverse effects. The research advances in the molecular epidemiology and clinical and therapeutic interventions of HCV genetic heterogeneity and single nucleotide polymorphisms in its host are reviewed. It is suggested that there is a pressing need for reliable data on the molecular epidemiology of HCV and its host, which will assist in the decision making of public health issues and reduce the morbidity and mortality of hepatitis C worldwide.