Impact of Larger Sputum Volume on Xpert® MTB/RIF Assay Detection of Mycobacterium tuberculosis in Smear-Negative Individuals with Suspected Tuberculosis

Sharlaa Badal-Faesen,Cynthia Firnhaber,Michelle A. Kendall,Xingye Wu,Beatriz Grinsztejn,Rodrigo Otavio da Silva Escada,Michel Fernandez,Evelyn Hogg,Ian Sanne,Pamela Johnson,David Alland,Gerald H. Mazurek,Debra A. Benator,Anne F. Luetkemeyer, the AIDS Clinical Trials Group A, Tuberculosis Trials Consortium Study Teams

Journal of Clinical Medicine（2017）

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摘要

As a strategy to improve the sensitivity of nucleic acid-based testing in acid-fast bacilli (AFB) negative samples, larger volumes of sputum (5–10 mL) were tested with Xpert® MTB/RIF from 176 individuals with smear-negative sputum undergoing tuberculosis evaluation. Despite larger volumes, this strategy had a suboptimal sensitivity of 50% (4/8).

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关键词

larger volume sputum,Xpert MTB/RIF,smear-negative suspects

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