Endothelial dysfunction in patients with rheumatoid arthritistreated with methotrexate

The aim of the work to study endothelial dysfunctionin young patients with rheumatoid arthritis (RA) treated with Methotrexate (MTX). The subjects of the study were 102 patients with RA. The Duplex study ofextracranial section sleepy and vertebral artery have shown beside sick RA in young age tortuosity sleepy and vertebral artery in 31,4% events with finding atherosclerotic plaque in 10,78% events, increase SUBJECT is revealed at study brahiocefalic artery beside 29,4% with age oscillation. Pathologic reactivity registered more often for the first time years from begin diseases and in 10 years then in interval from 5 before 10 years function of endothelia beside sick more often was normal. Also beside sick taken MTX more 2 years were more often revealed pathological reactivity.