Cross Match Incompatibilities in blood bank - A Perplexing Scenario

A safe transfusion is the one which provides specific and effective components which have a reasonably normal length of survival in the patient, doesn't cause any immediate or delayed reaction and, doesn't jeopardize the safety of future transfusions or transmit disease. Cross match provides a final chance to check ABO compatibility and a second chance to detect clinically significant antibodies. Incompatible cross match results are not an uncommon occurrence in Blood Bank. Knowledge of the various causes of incompatible cross match may be useful in formulating a logical and stepwise approach so as to provide safe transfusion to the recipient.