Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains

Simone Heber,Imre Gáspár,Jan-Niklas Tants,Johannes Günther,Sandra M. Fernandez Moya,Robert Janowski,Anne Ephrussi,Michael Sattler,Dierk Niessing

Nature Communications（2019）

引用 11|浏览3

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摘要

The Staufen family of RNA-binding proteins are conserved microtubule dependent mRNA transporter factors. Here the authors use biochemical and functional approaches to characterize the RNA-binding properties of mouse Staufen 2 and study the mRNA binding capacity of its two domains dsRBDs 1 and 2.

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