High throughput pMHC-I tetramer library production using chaperone-mediated peptide exchange

Sarah A. Overall,Jugmohit S. Toor,Stephanie Hao,Mark Yarmarkovich,Sara M. O’Rourke,Giora I. Morozov,Son Nguyen,Alberto Sada Japp,Nicolas Gonzalez,Danai Moschidi,Michael R. Betts,John M. Maris,Peter Smibert,Nikolaos G. Sgourakis

Nature Communications（2020）

引用 24|浏览7

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摘要

Peptide-MHC (pMHC) tetramers are important tools for probing T cell repertoire and adaptive immune responses. Here the authors use a molecular chaperone, TAPBPR, to develop a high-throughput, multiplexible platform for pMHC tetramer generation to facilitate simultaneous assessments of T cell repertoire/antigen specificity and transcriptome.

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关键词

Cellular immunity,Immunochemistry,MHC class I,Translational immunology,Science,Humanities and Social Sciences,multidisciplinary

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