Hiv associated lymphoma – two case report series

Combined antiretroviral therapy significantly improved the prognosis and the life expectancy of HIV patients. Along with this, the profile of HIV associated malignant pathologies has changed. Among these, lymphoma, with a higher incidence than in general population, are an important cause of mortality and morbidity in HIV infected people. We present two cases of HIV-associated lymphoma. In the first case, a newly HIV diagnosed patient, with a good immunological status, developed non-Hodgkin´s Burkitt-type lymphoma and he had a fulminant evolution towards death. In the second case, a patient known for over twenty years with HIV infection and who had discordant immunological and virusological response to antiretroviral therapy, was diagnosed with Hodgkin´s lymphoma and he had a favorable evolution with chemotherapy. Both patients required exhaustive medical investigations and a close interdisciplinary cooperation during the entire time of diagnostic and therapeutic procedures.