A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer

David W. Basta,Mandy Vong,Adolat Beshimova,Brooke N. Nakamura,Iulia Rusu,Michael G. Kattah,Ling Shao

Gastro Hep Advances（2023）

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摘要

Mechanistically, we propose that A20 normally restricts tumor necrosis factor-induced nuclear factor kappa B-dependent production of iNOS in intestinal epithelial cells, thereby protecting against colitis-associated tumorigenesis. We also propose that A20 plays a direct role in regulating NO-dependent cell death.

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关键词

Colon,Ulcerative colitis,Inflammation,Nitric oxide,A20,Tnfaip3,Tumor

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