Encapsulation of (E)-N’-(1-(7-(diethylamino)-2-oxo-2H-chromen-3 yl)ethylidene)benzohydrazide (7-diEAHC) in β-cyclodextrins: Optimized synthesis of 7-diEACH and in silico ADME profiling, physical stability, antioxidant properties of encapsulated 7-diEAHC and bioavailability in rats

Emna Khdhiri,Souhir Abid,Khaled Athmouni,Majdi Abid,Habib Ayadi,Houcine Ammar,Ludovic Paquin,Jean-Pierre Bazureau

Results in Chemistry（2023）

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摘要

•(E)-N’-(1-(7-(Diethylamino)-2-oxo-2H-chromen-3 yl)ethylidene)benzohydrazide.•Box-Behnken design for optimized synthesis.•Lipinski’s descriptors.•ADME descriptors.•β-Cyclodextrins.•Micro-encapsulation.•Bioavailability.

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关键词

Hydrazone coumarin,β-Cyclodextrins,Optimization,ADME parameters,Micro-encapsulation,Bio-assay

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