Continuous precipitation of antibodies by feeding of solid polyethylene glycol

Maria del Carme Pons Royo, Tommaso De Santis,Daniel Komuczki,Peter Satzer,Alois Jungbauer

Separation and Purification Technology（2023）

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摘要

•PEG6000 in powder form was dissolved within minutes.•Continuous protein precipitation with solid PEG6000 was performed during 4 h.•Direct addition of PEG shows comparable yield and purity as liquid PEG addition.•Manufacturing costs are reduced by 45 % by the direct addition of PEG6000.•Carbon footprint is reduced by 60 %

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关键词

Monoclonal antibodies,Continuous precipitation,Solid PEG,IgG,SuperPro Designer,Protein A affinity chromatography

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