NBS promoted cascade reaction of beta-anhydroicaritine and alcohols
Green Chemistry Letters and Reviews(2023)
Abstract
An unusual NBS promoted cascade reaction of beta-anhydroicaritine and alcohols was successfully developed to prepare chromane-3,4-dione 3 in a moderate yield. A mechanism was also put forward to explain this reaction. These chromane-3,4-dione derivatives showed a potent cytotoxicity against HepG2 and MCF-7 cell lines, which were expected to be a potential lead candidate for the treatment of liver cancer and breast cancer.
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Key words
Bromination,icaritin,beta-anhydroicaritine,cascade reaction,chromane-3,4-dione
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