c-Myc-IMPDH1/2 axis promotes tumourigenesis by regulating GTP metabolic reprogramming.

Qiang Zhang,Kaisa Cui,Xiaoya Yang,Qilang He,Jing Yu,Li Yang, Gang Yao, Weiwei Guo,Zhanhao Luo,Yugeng Liu, Yuan Chen,Zhen He,Ping Lan

Clinical and translational medicine（2023）

引用 8|浏览21

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摘要

Our study highlights the essential roles of metabolic rate-limiting enzymes in tumourigenesis and their crosstalk with Myc, and the Myc-IMPDH1/2 axis promotes tumourigenesis by altering GTP metabolic reprogramming. Our results propose the inhibition of IMPDH1 as a viable option for cancer treatment.

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关键词

GTP,IMPDH1,IMPDH2,c-Myc,colorectal carcinoma,metabolic rate-limiting enzymes

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