Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5'-methylene substituted 2',5'-deoxyribonucleotides.

Nan-Sheng Li,Joseph A. Piccirilli,Geoffrey L. Greene

Nucleosides, nucleotides & nucleic acids（2023）

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摘要

We describe a new demethylation method for dimethyl phosphonate esters using sodium ethanethiolate. The new procedure allows demethylation of nucleoside dimethyl phosphonate esters without 1'-α-anomerization, providing an improved synthesis of 5'-methylene substituted 2',5'-deoxynucleotides.

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关键词

5′-methylene dNMP,5′-methylene dNTP,5′-methylene substituted 2′,5′-deoxynucleotides,Demethylation,dimethyl phosphonate esters,sodium ethanethiolate

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