Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer.

Simonetta M Leto,Martina Ferri,Francesco Sassi,Eugenia R Zanella,Francesca Cottino,Valentina Vurchio,Irene Catalano,Alessandro Ferrero,Caterina C Zingaretti,Caterina Marchiò,Elena Grassi,Livio Trusolino,Andrea Bertotti

Clinical cancer research : an official journal of the American Association for Cancer Research（2023）

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摘要

In mCRC tumors that respond to cetuximab, antibody treatment confers a synthetic-lethal dependency on BCL-XL. Targeting this dependency unleashes apoptosis and increases the depth of response to cetuximab.

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关键词

colorectal cancer,cetuximab,patient-derived

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