Standardized RS Ratio Metrics To Assess Tuberculosis Antimicrobial Efficacy and Potency.

Matthew J Reichlen,Sarah E M Born,Michael A Lyons,Karen Rossmassler,Justin Reid,Gregory T Robertson,Nicholas D Walter,Martin I Voskuil

Antimicrobial agents and chemotherapy（2023）

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摘要

The sigmoid E model was used to describe the rRNA synthesis ratio (RS ratio) response of Mycobacterium tuberculosis to antimicrobial concentration. RS-E measures the maximal ability of a drug to inhibit the RS ratio and can be used to rank-order drugs based on their RS ratio effect. RS-EC is the concentration needed to achieve 90% of the RS-E, which may guide dose selection to achieve a maximal RS ratio effect .

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关键词

Mycobacterium tuberculosis,RS ratio,antibiotic,antimicrobial,drug effects,drug therapy,precursor rRNA

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