Dihydropyrimidinase-like 2 can serve as a novel therapeutic target and prognostic biomarker in acute myeloid leukemia.

Fenglin Li,Qing Ling,Jiaying Lian,Ying Chen,Chao Hu,Min Yang,Xiang Zhang,Chenying Li,Shihui Mao,Wenle Ye,Xia Li,Xiangjie Lin,Wenwen Wei,Xin Huang,Jiajia Pan,Yu Qian,Jinghan Wang,Ying Lu,Jie Jin

Cancer medicine（2023）

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摘要

We first time confirmed that DPYSL2 was a target of HHT and played an oncogene role in AML by regulating JAK/STAT signaling pathway. Therefore, DPYSL2 could serve as a novel prognostic marker and therapeutic target for AML treatment.

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关键词

AML,DPYSL2,HHT,PI3K/Akt,biomarker,prognostic

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