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Human pegivirus-1 replication influences NK cell reconstitution after allogeneic haematopoietic stem cell transplantation.

Amandine Pradier,Samuel Cordey,Marie-Céline Zanella,Astrid Melotti,Sisi Wang,Anne-Claire Mamez,Yves Chalandon,Stavroula Masouridi-Levrat,Laurent Kaiser,Federico Simonetta,Diem-Lan Vu

Frontiers in immunology（2022）

Cited 5|Views12
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Abstract
Our study shows that HPgV-1-viremic allo-HSCT recipients displayed an impaired NK cell, but not T cell, immune-reconstitution compared with HPgV-1-non-viremic patients, revealing for the first time a potential association between replication of the non-pathogenic HPgV-1 virus and immunomodulation after allo-HSCT.
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CD16,CD57,NK cell,granzyme B,human pegivirus-1,stem cell,transplantation
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