Replacing animal-derived components in in vitro test guidelines OECD 455 and 487
Science of The Total Environment(2023)
摘要
The evaluation of single substances or environmental samples for their genotoxic or estrogenic potential is highly relevant for human- and environment-related risk assessment. To examine the effects on a mechanism-specific level, standardized cell-based in vitro methods are widely applied. However, these methods include animal-derived components like fetal bovine serum (FBS) or rat-derived liver homogenate fractions (S9-mixes), which are a source of variability, reduced assay reproducibility and ethical concerns.
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关键词
Fetal bovine serum,Chemically defined media,S9,Estrogenic activity,Genotoxicity
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