Ruthenium-catalyzed reductive amination of ketones with nitroarenes and nitriles.
Organic & biomolecular chemistry(2023)
Abstract
The Ru(dppbsa)-catalyzed reductive amination of ketones with nitroarenes and nitriles using H as the environmentally benign hydrogen surrogate is developed in this study. Cross-experiments demonstrated that both reactions are initiated by the reduction of nitroarenes or nitriles to the corresponding amines, followed by condensation with ketones to give imines and thereafter hydrogenation. However, the route to the formation of an amino-ligated Ru complex during the reduction of nitroarenes or nitriles, followed by nucleophilic C-N coupling, cannot be completely excluded. This newly developed versatile method features good functional group tolerance, which provides a novel design platform for homogeneous catalysts in constructing motifs of secondary amines.
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Key words
reductive amination,nitroarenes,ketones,nitriles,ruthenium-catalyzed
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