Biofilm microenvironment response nanoplatform synergistically degrades biofilm structure and relieves hypoxia for efficient sonodynamic therapy

•MAPC as a novel biofilm microenvironment-responsive nanoplatform can decompose in the acidic biofilm microenvironment and subsequently releases the α-amylase, manganese oxide and sonosensitizer.•MAPC released α-amylase can selectively degrade the extracellular polymeric substances of MRSA biofilms and further promotes the sonosensitizer penetration.•MAPC released manganese oxide with catalase-like activity can convert the overproduced H2O2 into O2 to relieve the hypoxic biofilm microenvironment, which significantly enhances the sonodynamic antimicrobial efficiency.•MAPC offers an effective therapeutic strategy for superior MRSA biofilm eradication efficiency of combining biofilm structure degradation with improved ultrasound-driven antimicrobial sonodynamic therapy by hypoxia relief.