F4/80+Ly6Chigh Macrophages Lead to Cell Plasticity and Cancer Initiation in Colitis

Alice E. Shin,Yodit Tesfagiorgis,Frederikke Larsen,Mathieu Derouet,Peter Y.F. Zeng, Hayley J. Good,Liyue Zhang,Mara R. Rubinstein,Yiping W. Han,Steven M. Kerfoot,Anthony C. Nichols,Yoku Hayakawa,Christopher J. Howlett,Timothy C. Wang,Samuel Asfaha

Gastroenterology（2023）

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摘要

We have identified CD11bF4/80Ly6C macrophages as key mediators of cancer initiation in colitis-associated cancer. Development of new therapies that target these cells may provide an effective preventative strategy for colitis-associated cancer.

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关键词

AOM/DSS,Dclk1,colitis,colorectal cancer,macrophages

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