A QSPR study for predicting (LCST) and (UCST) in binary polymer solutions

Lower critical solution temperature (LCST) and upper critical solution temperature (UCST) are key ther-modynamic properties of binary polymer solutions. In this work, quantitative structure property relation-ship (QSPR) modeling was employed to predict theta(LCST) and theta(UCST) (LCST and UCST at the limit of infinite molar mass). Based on a series of topological norm descriptors and quantum chemical norm descriptors derived exclusively from the chemical structures of polymers and solvents, four linear topological and spatial LCST-QSPR and UCST-QSPR models were developed. The accuracy, robustness, and predictability of the proposed models were evaluated in detail by various statistical parameters (e.g., R2, MAE, MRE, and RMSE) and validation approaches (e.g., leave-one-out cross validation and Y-randomized validation). Various validation techniques and statistical indicators reveal that the spatial LCST-QSPR and UCST-QSPR models established by adding quantum chemical norm descriptors show better performances. Desirable agreements (Rtraining 2 = 0.9423) between calculated and experimental theta(LCST) of 118 training set polymer solutions can be found in the spatial LCST-QSPR model as demonstrated by MRE of 2.65 %. Meanwhile, the spatial UCST-QSPR model shows the performances with MRE of 8.03 % and Rtraining 2 of 0.8826 of 87 training set polymer solutions. The comparative results with those of different models from literatures further confirm the advantages of the as-developed models. The presented QSPR models are expected for rapid and accurate prediction of the Theta(LCST) and Theta(UCST) values of various binary polymer solutions. (c) 2022 Elsevier Ltd. All rights reserved.