Procyanidin B2 3,3″-di-O-gallate suppresses IFN-γ production in murine CD4+ T cells through the regulation of glutamine influx via direct interaction with ASCT2

Katsunori Endo,Toko Sawa,Hidemitsu Kitamura,Koji Umezawa,Hidefumi Makabe,Sachi Tanaka

International Immunopharmacology（2023）

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摘要

•Procyanidin gallate, a polyphenol, suppresses glutamine influx in CD4+ T cells.•Glutamine supplementation abrogates the inhibition of IFN-γ by procyanidin gallate.•Reduction of glutamine influx by procyanidin gallate induces ATF4 expression.•Procyanidin gallate binds to the transporter ASCT2 to block production of IFN-γ.

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关键词

Procyanidin B2 gallate,IFN-γ,Glutamine,ASCT2,Target protein

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