抗Homer3抗体阳性自身免疫性小脑共济失调1例并文献复习

Chinese Journal of Neurology(2022)

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Abstract
自身免疫性小脑性共济失调(ACA)是一种自身免疫机制介导的小脑综合征,抗Homer蛋白3(Homer3)抗体阳性的ACA十分罕见。文中报道1例山东大学齐鲁医院收治的患者,55岁男性,主因“头晕、行走不稳22 d”就诊,血清及脑脊液检测结果示抗Homer3抗体阳性,给予静脉注射免疫球蛋白联合激素治疗,症状好转。通过对该病例资料及相关文献报道的复习,分析抗Homer3抗体阳性ACA的发病机制、临床表现、辅助检查、治疗及预后,加深临床医生对其的认识,提高诊治水平。
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Key words
Cerebellar ataxia,Autoimmunity,Homer3 protein,Metabolic glutamate receptor type 1,Shank protein
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