Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier.

Hsuan-Ju Lai,Ha T Doan,Elliot Y Lin,Yi-Ling Chiu,Yuan-Kai Cheng,Yi-He Lin,Hao-Sen Chiang

Inflammatory bowel diseases（2023）

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摘要

PAD4-mediated NET formation has a detrimental role in acute colitis. NET-associated histones directly inhibit intestinal barrier function, resulting in cytotoxicity in vitro and in vivo.

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关键词

adherens junctions,histones,intestinal barrier permeability,intestinal epithelial cells,neutrophil extracellular traps,peptidyl arginine deiminase 4,tight junctions

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