Effect of sulfadoxine-pyrimethamine chemoprophylaxis in pregnant women on selection of the new P. falciparum dhps quintuple mutant carrying the I431V mutation.

Olivia Cohen,Emilie Guemas,Sandie Menard, Martial Tsague Kenfack, Carine Talom Ngassa,Xavier Iriart, Marlise Bidzogo Lebobo, Celestin Ondobo Ekae,Carole Eboumbou, Calvin Tiyou Kenmeni,Antoine Berry

The Journal of antimicrobial chemotherapy（2023）

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摘要

We found a strong overrepresentation of the CirnI/vagKgs haplotype in the IPTp-SP pregnant group, suggesting a high level of resistance of this mutant to SP. This could compromise not only the effectiveness of IPTp-SP but also the seasonal malaria chemoprevention of young children, now widely implemented.

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关键词

dhps</i>quintuple mutant,pregnant women,sulfadoxine-pyrimethamine

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