Decomplexation proteomic analysis and purity assessment of a biologic for snakebite envenoming: Philippine Cobra Antivenom.

Praneetha Palasuberniam,Kae Yi Tan,Yi Wei Chan,Francis Bonn Blanco,Choo Hock Tan

Transactions of the Royal Society of Tropical Medicine and Hygiene（2023）

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摘要

Together, the findings show that PCAV contains a favorable content of F(ab')2 for neutralization, while the antibody purification process awaits improvement to minimize the presence of protein impurities.

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关键词

drug evaluation,preclinical,quality control,size exclusion chromatography,snakebite envenomation,tandem mass spectrometry

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