Curcumin treatment suppresses cachexia-associated adipose wasting in mice by blocking the cAMP/PKA/CREB signaling pathway

Ranran Wang,Lulu Wei,Junaid Wazir,Li Li,Shiyu Song,Kai Lin,Wenyuan Pu,Chen Zhao,Zhonglan Su,Quan Zhao,Hongwei Wang

Phytomedicine（2023）

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摘要

•Curcumin protected against cachectic weight loss in C26 tumor-bearing mice.•Curcumin alleviated cancer cachexia-associated adipocyte atrophy and lipid degradation.•The protective effects of curcumin on cachectic fat loss are mediated by the cAMP/PKA/CREB signaling pathway.

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关键词

Curcumin,Cancer cachexia,Lipolysis,CL316243,cAMP/PKA/CREB

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