Response to Letter to the Editor by Palffy and Ghaziuddin

American Journal of Medical Genetics Part AVolume 191, Issue 5 p. 1470-1473 RESEARCH LETTER Response to Letter to the Editor by Palffy and Ghaziuddin Stephanie L. Santoro, Corresponding Author Stephanie L. Santoro [email protected] orcid.org/0000-0002-4172-0288 Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Correspondence Stephanie L. Santoro, Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, 125 Nashua St., Suite 821, Boston, MA 02114, USA. Email: [email protected]Search for more papers by this authorNicole T. Baumer, Nicole T. Baumer orcid.org/0000-0003-2170-3058 Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorMichelle Cornacchia, Michelle Cornacchia Geisinger Health System, Danville, Pennsylvania, USASearch for more papers by this authorCatherine Franklin, Catherine Franklin Mater Research Institute-University of Queensland, The University of Queensland, South Brisbane, AustraliaSearch for more papers by this authorSarah J. Hart, Sarah J. Hart orcid.org/0000-0003-0974-3209 Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USASearch for more papers by this authorKelsey Haugen, Kelsey Haugen Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorMargaret A. Hojlo, Margaret A. Hojlo orcid.org/0000-0003-3757-9776 Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorNora Horick, Nora Horick Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorPriya S. Kishnani, Priya S. Kishnani Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USASearch for more papers by this authorKavita Krell, Kavita Krell orcid.org/0000-0002-7905-871X Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorAndrew McCormick, Andrew McCormick Down Syndrome Center of Western Pennsylvania, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorAnna L. Milliken, Anna L. Milliken Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorNicolas M. Oreskovic, Nicolas M. Oreskovic orcid.org/0000-0001-8702-8636 Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this authorKatherine G. Pawlowski, Katherine G. Pawlowski Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorSabrina Sargado, Sabrina Sargado Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorAmy Torres, Amy Torres Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorDiletta Valentini, Diletta Valentini Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, Rome, ItalySearch for more papers by this authorKishore Vellody, Kishore Vellody orcid.org/0000-0002-2116-6486 Down Syndrome Center of Western Pennsylvania, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorBrian G. Skotko, Brian G. Skotko orcid.org/0000-0002-5232-9882 Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this author Stephanie L. Santoro, Corresponding Author Stephanie L. Santoro [email protected] orcid.org/0000-0002-4172-0288 Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Correspondence Stephanie L. Santoro, Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, 125 Nashua St., Suite 821, Boston, MA 02114, USA. Email: [email protected]Search for more papers by this authorNicole T. Baumer, Nicole T. Baumer orcid.org/0000-0003-2170-3058 Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorMichelle Cornacchia, Michelle Cornacchia Geisinger Health System, Danville, Pennsylvania, USASearch for more papers by this authorCatherine Franklin, Catherine Franklin Mater Research Institute-University of Queensland, The University of Queensland, South Brisbane, AustraliaSearch for more papers by this authorSarah J. Hart, Sarah J. Hart orcid.org/0000-0003-0974-3209 Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USASearch for more papers by this authorKelsey Haugen, Kelsey Haugen Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorMargaret A. Hojlo, Margaret A. Hojlo orcid.org/0000-0003-3757-9776 Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorNora Horick, Nora Horick Biostatistics Center, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorPriya S. Kishnani, Priya S. Kishnani Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USASearch for more papers by this authorKavita Krell, Kavita Krell orcid.org/0000-0002-7905-871X Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorAndrew McCormick, Andrew McCormick Down Syndrome Center of Western Pennsylvania, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorAnna L. Milliken, Anna L. Milliken Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorNicolas M. Oreskovic, Nicolas M. Oreskovic orcid.org/0000-0001-8702-8636 Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this authorKatherine G. Pawlowski, Katherine G. Pawlowski Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorSabrina Sargado, Sabrina Sargado Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Boston Children's Hospital Down Syndrome Program, Boston Children's Hospital, Boston, Massachusetts, USASearch for more papers by this authorAmy Torres, Amy Torres Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USASearch for more papers by this authorDiletta Valentini, Diletta Valentini Pediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, Rome, ItalySearch for more papers by this authorKishore Vellody, Kishore Vellody orcid.org/0000-0002-2116-6486 Down Syndrome Center of Western Pennsylvania, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorBrian G. Skotko, Brian G. Skotko orcid.org/0000-0002-5232-9882 Down Syndrome Program, Division of Medical Genetics and Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USASearch for more papers by this author First published: 06 January 2023 https://doi.org/10.1002/ajmg.a.63116Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES Anthonio, G., Malik, F., Ghomeshi, A., Lopez, O., & Gralnik, L. (2022). 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