Si-Ni-San reduces lipid droplet deposition associated with decreased YAP1 in metabolic dysfunction-associated fatty liver disease.

Kangning Zheng,Wenhan Zhou,Jingmin Ji,Yu Xue,Yiwei Liu,Caige Li,Zhiqin Zhang,Junlan Lu,Xinli Shi,Yongmin Li

Journal of ethnopharmacology（2023）

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摘要

SNS reduced LD deposition and YAP1 expression in MAFLD liver cells both in vivo and in vitro. YAP1 was highly expressed in livers with MAFLD, and knockout of hepatocellular YAP1 reduced LD deposition in mice. SNS reduced LD deposition associated with decreased YAP1 in MAFLD liver cells.

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关键词

Lipid droplet,Metabolic dysfunction-associated fatty liver disease,PLIN2,Si-Ni-San,YAP1

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