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Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells and promote liver fibrosis via the MAPK/STMN1 axis activation

Bin Liu,Jinchao Wang,Guangchuan Wang,Wanli Jiang,Zhen Li,Yongjun Shi,Junyong Zhang,Qingshan Pei,Guangjun Huang,Lifen Wang,Shengqiang Zhao,Lei Wu,Mingyan Zhang,Wenwen Wang,Xiao Li,Tong Mou,Chunqing Zhang,Qian Ding

International Immunopharmacology（2023）

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Abstract
•H2AFJ is upregulated in hepatocyte-derived exosomes in CCl4-stimulated liver fibrosis.•H2AFJ upregulates STMN1 by activating the MAPK signaling pathway.•Exosomal H2AFJ from hepatocytes promotes HSC activation.•H2AFJ silencing relieves liver fibrosis in mice by suppressing MAPK/STMN1 activation.•The study unveils a potential therapeutic target for treating liver fibrosis.
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Key words
Hepatocytes,Exosomes,H2AFJ,Liver fibrosis,Hepatic stellate cells,MAPK,STMN1
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