New polychlorinated bibenzyls from Rhododendron minutiflorum
Natural Products and Bioprospecting(2023)
Abstract
Five new polychlorinated bibenzyls ( 1 – 5 ) along with 3 known compounds ( 6 – 8 ) were isolated from the stems and leaves of Rhododendron minutiflorum . The chemical structures of all the isolates were determined by spectroscopic methods, and compounds 1 and 2 were further verified by single-crystal X-ray diffraction analyses. Compounds 1 – 5 were halogenated compounds which bear three to five chlorine atoms in their chemical structures. Biologically, compounds 2 , 5 and 6 showed varying degrees of toxicity toward the Asian citrus psyllid ( Diaphorina citri ) with LD 50 values 27.15, 17.02 and 16.20 mg/L, respectively. These values were comparable to the positive control matrine (LD 50 = 11.86 mg/L), which were calculated using observations on day 6. Meanwhile, compound 4 had α -glucosidase inhibitory activity with IC 50 value of 17.87 ± 0.74 μ M. Graphical Abstract
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Key words
Rhododendronminutiflorum,Polychlorinated bibenzyls,Matrine,Insecticidal activity,Diaphorinacitri,α-Glucosidase inhibitory activity,Acarbose
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