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Ciprofloxacin chitosan conjugate: combined antibacterial effect and low toxicity

Anton R. Egorov,Margarita N. Kurasova,Omar Khubiev, Nikita A. Bogdanov,Alexander G. Tskhovrebov, Analoly A. Kirichuk, Victor N. Khrustalev,Vasili V. Rubanik,Andreii S. Kritchenkov

Mendeleev Communications（2022）

Cited 2|Views3
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Abstract
Ultrasound-mediated reaction of chitosan with ciprofloxacin in the presence of N,N'-dicyclohexylcarbodiimide in water gives the chitosan–ciprofloxacin conjugates of carboxamide type. The conjugates show a mediate antibacterial effect and reduced cytotoxicity.
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Key words
ciprofloxacin,chitosan,conjugates,carboxamides,ultrasound treatment,antibacterial activity,toxicity
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